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A new drug approved for weight-loss with the U.S. Food and Drug Administration had accomplishment in many studies, nonetheless it isn't a panacea for weight loss. It must be used in combination with a low-calorie diet and physical exercise in order to be effective. Using two separate drugs to shed pounds can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with fat loss and the individuals who go through it you ought to err along the side of caution and allow FDA do its job and demand some investigation be done so the public understands the side effects and risks of the medications before we take them. Keep in mind that drug companies have been in business to make money and that they would say almost anything to keep people on their medications. Researchers found out that participants investing in this drug for a year, lost excess weight within one month and have kept the weight off during the entire 56 weeks from the study. Contrave can be a combination in the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs that are made up of more than one active ingredient, which might make them more efficient and safer. Combo-pilling is the newest fad or even better the newest into the future under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is now popular is the fact that by right now there aren't any long term prescription slimming capsules that have been approved by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be authorized by the FDA. Seizures can be a side effect with Contrave and mustn't be taken in those with seizure disorders. The drug could also raise blood pressure level and heartrate, and must not be used in people who have a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure level and heartbeat and must not be used in patients with uncontrolled high hypertension, in addition to by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients with a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert physicians and patients to the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking. "This may be the first drug I'm alert to that targets both the appetite and reward centres within the brain," he explained.